Biocurious is a weblog about biology, quantified.

Mapping the mind of a worm, one synapse at a time

by Andre on 25 June 2014

John White is a legendary scientist who, with Eileen Southgate, mapped the wiring diagram of the entire nervous system of C. elegans. This is still the only complete wiring diagram, or connectome, that we have for any animal, a feat that’s all the more impressive given that it was started in the early ’70s. And you can now read a first-person description of how it happened in the history section of WormBook:

Getting into the mind of a worm—a personal view

Check it out and read about the atmosphere at the LMB and the joys of working with early computers. The basic procedure for reconstructing the mind of a worm was to cut it into very thin sections, image them with an electron microscope, and then find the cells, processes, and synapses in consecutive sections to figure out what’s connected to what. Here’s an example of a series of images from Dan Bumbarger who works on worm connectomics today:

Reconstructing all the connections is not an easy task even if you don’t have to write your own graphics software, but in 1970, it was, shall we say, an ambitious PhD project. Which brings me to my favourite quote from the piece:

Sydney [Brenner] seemed a bit like the Pied Piper of Hamelin on speed—leading all who followed into the unknown.

This is the first worm history entry that’s actually written for and hosted on the WormBook site. I hope it’s the first of many.



  1. tenda router support    161 days ago    #

    it is really nice. I always come across interesting articles like this one.


  2. Hookup Apps    160 days ago    #

    If girls like this gesture of you then continue with that touch her hand very lightly and continue with that.


  3. Gmail Support    159 days ago    #

    I like the above-shared article very much.
    Keep updating us with these types of informative posts.


  4. canon printer support    124 days ago    #

    nice post. please share an update.
    <a href=“https://ajitchaudhary1892.wixsite.com/canonsupport/single-post/2017/07/27/Canon-Printer-Vs-HP-Printer-Which-one-is-The-Best”> Canon Support</a>


  5. canon printer support    124 days ago    #

    nice post. please share an update related to post.


  6. Pay Someone To Take My Online Exam    109 days ago    #

    I appreciate your efforts in preparing this post. I really like your blog articles.


  7. uk best essay    69 days ago    #

    This research is good for the medical student because it has information about the worm and yes it’s very unique content because everyone know about the worm and its size. I’m still thinking in which way they acknowledge the mapping of mind of a worm then suddenly i thought nothing is impossible now with the presence of latest Technology.


  8. Black magic removal    66 days ago    #

    what a great blog you have made for us and we also appreciate you and keep update and posting so your blog can get more visitor. Thank you man like it.


  9. Vizag Escorts Services    54 days ago    #

    I wonder to see your blog and you too man. Very informatics blog you created for needy person. I like and appreciate you man.


  10. Cara Mengobati Gusi Bengkak    34 days ago    #

    This information is very useful. thank you for sharing. and I will also share information about health through the website

    <a href=“http://www.herbalqncjellygamat.com/cara-menghilangkan-bruntusan-diwajah-secara-alami-efektif/”>Cara Menghilangkan Bruntusan</a>
    <a href=“http://www.herbalqncjellygamat.com/obat-penyakit-anyang-anyangan-susah-kencing-alami-dan-ampuh/”>Obat Penyakit Susah Kencing</a>
    <a href=“http://www.herbalqncjellygamat.com/cara-mengobati-gondok-beracun-dengan-cepat/”>Cara Mengobati Gondok Beracun</a>
    <a href=“http://www.herbalqncjellygamat.com/cara-mengobati-gabagen/ “>Cara Mengobati Gabagen</a>
    <a href=“http://www.herbalqncjellygamat.com/cara-mudah-mengobati-diabetes-sampai-tuntas/”>Cara Mudah Mengobati Diabetes</a>
    <a href=“http://www.herbalqncjellygamat.com/cara-menyembuhkan-mata-minus-secara-alami-dengan-cepat/ “>Cara Menyembuhkan Mata Minus</a>


Name
Email
http://
Message
  Textile help